Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures

Neto2 is a transmembrane protein that interacts with the neuron-specific K+-Cl- cotransporter (KCC2) in the CNS. Efficient KCC2 transport is essential for setting the neuronal Cl- gradient, which is required for fast GABAergic inhibition. Neto2 is required to maintain the normal abundance of KCC2 in...

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Bibliographic Details
Main Authors: Vivek eMahadevan, Zahra eDargaei, Evgueni eIvakine, Anna-Maria eHartmann, David eNg, Jonah eChevrier, John eOrmond, Hans Gerd Nothwang, Roderick eMcInnes, Melanie A Woodin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Chlorides
Hippocampus
chloride
GABA
inhibition
KCC2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00368/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00368/full

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