Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD
<p>Abstract</p> <p>Background</p> <p>Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFβ induced Smad pathway...
Main Authors: | Noordhoek Jacobien A, Jonker Marnix R, Postma Dirkje S, Zandvoort Andre, Vos Johannes TWM, Timens Wim |
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Format: | Article |
Language: | English |
Published: |
BMC
2008-12-01
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Series: | Respiratory Research |
Online Access: | http://respiratory-research.com/content/9/1/83 |
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