Coevolutionary methods enable robust design of modular repressors by reestablishing intra-protein interactions
Genetic sensors can be created by mix and matching DNA-binding modules with ligand-binding modules. Here the authors use a computational model to overcome module incompatibilities and restore function by rescuing key interactions.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25851-6 |