Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial

Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial

Abstract Background Acute respiratory distress syndrome (ARDS) is a complex clinical diagnosis with various possible etiologies. One common feature, however, is pulmonary permeability edema, which leads to an increased alveolar diffusion pathway and, subsequently, impaired oxygenation and decarboxyl...

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Bibliographic Details
Main Authors: Benedikt Schmid, Markus Kredel, Roman Ullrich, Katharina Krenn, Rudolf Lucas, Klaus Markstaller, Bernhard Fischer, Peter Kranke, Patrick Meybohm, Bernhard Zwißler, Sandra Frank, and the Solnatide Collaborators Group
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Trials
Subjects:
Acute respiratory distress syndrome
Solnatide
Extravascular lung water
Pulmonary edema
Critical care
Online Access:https://doi.org/10.1186/s13063-021-05588-9

Internet

https://doi.org/10.1186/s13063-021-05588-9

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