Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer

Abstract Background We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC). Methods Changes in glycolysis-related molecules and glycolytic activity were evaluated in PD-L1low and PD-L1high NSCLC cells after transfection or knockdown of PD-L1, respectiv...

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Main Authors: Sehui Kim, Ji-Young Jang, Jaemoon Koh, Dohee Kwon, Young A. Kim, Jin Chul Paeng, Chan-Young Ock, Bhumsuk Keam, Miso Kim, Tae Min Kim, Dae Seog Heo, Doo Hyun Chung, Yoon Kyung Jeon
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Programmed cell death-ligand-1
Hexokinase 2
Glycolysis
Non-small cell lung cancer
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s13046-019-1407-5

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http://link.springer.com/article/10.1186/s13046-019-1407-5

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