An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

Cancer stemness is associated with high malignancy and low differentiation, as well as therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC). Fibroblast growth factors (FGFs) exert pleiotropic effects on a variety of cellular processes and functions including embryonic s...

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Bibliographic Details
Main Authors: Mei-Yu Quan, Qiang Guo, Jiayu Liu, Ruo Yang, Jing Bai, Wei Wang, Yaxin Cai, Rui Han, Yu-Qing Lv, Li Ding, Daniel D. Billadeau, Zhenkun Lou, Saverio Bellusci, Xiaokun Li, Jin-San Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
FGFR
SOX2
pancreatic cancer
stemness
sphere-formation assay
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00287/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00287/full

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