Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution

Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution

Invasive outcomes of Group A Streptococcus (GAS) infections that involve damage to skin and other tissues are initiated when these bacteria colonize and disseminate via an open wound to gain access to blood and deeper tissues. Two critical GAS virulence factors, Plasminogen-Associated M-Protein (PAM...

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Bibliographic Details
Main Authors: Henry M. Vu, Daniel E. Hammers, Zhong Liang, Gabrielle L. Nguyen, Mary E. Benz, Thomas E. Moran, Dustin L. Higashi, Claudia J. Park, Yetunde A. Ayinuola, Deborah L. Donahue, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
plasminogen
plasmin
fibrinolysis
Streptococcus pyogenes
live imaging microscopy
wound retraction
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.667554/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.667554/full

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