Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections

The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex. Complement activation liberates the anaphylatoxins C3a and C5a, which activate three distinct G-protein coupled receptors, C3a...

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Bibliographic Details
Main Authors: Marcel Muenstermann, Lea Strobel, Andreas Klos, Rick A. Wetsel, Trent M. Woodruff, Jörg Köhl, Kay O. Johswich
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Virulence
Subjects:
c3a
c5a
Online Access:http://dx.doi.org/10.1080/21505594.2019.1640035