Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections
The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex. Complement activation liberates the anaphylatoxins C3a and C5a, which activate three distinct G-protein coupled receptors, C3a...
Main Authors: | Marcel Muenstermann, Lea Strobel, Andreas Klos, Rick A. Wetsel, Trent M. Woodruff, Jörg Köhl, Kay O. Johswich |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2019-01-01
|
Series: | Virulence |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/21505594.2019.1640035 |
Similar Items
-
The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist
by: Xaria X. Li, et al.
Published: (2021-01-01) -
Differential Contributions of the Complement Anaphylotoxin Receptors C5aR1 and C5aR2 to the Early Innate Immune Response against Staphylococcus aureus Infection
by: Sarah A. Horst, et al.
Published: (2015-10-01) -
C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis
by: Quan-you Zheng, et al.
Published: (2019-08-01) -
Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis
by: Haitao A. Wang, et al.
Published: (2017-06-01) -
Insights into the Complement System of Tunicates: C3a/C5aR of the Colonial Ascidian <i>Botryllus schlosseri</i>
by: Anna Peronato, et al.
Published: (2020-09-01)