A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-γ in host resistance to infection.

A model of DENV-3 infection that recapitulates severe disease and highlights the importance of IFN-γ in host resistance to infection.

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was prece...

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Bibliographic Details
Main Authors: Vivian V Costa, Caio T Fagundes, Deborah F Valadão, Daniel Cisalpino, Ana Carolina F Dias, Kátia D Silveira, Lucas M Kangussu, Thiago V Ávila, Maria Rosa Q Bonfim, Daniela Bonaventura, Tarcília A Silva, Lirlândia P Sousa, Milene A Rachid, Leda Q Vieira, Gustavo B Menezes, Ana Maria de Paula, Alena Atrasheuskaya, George Ignatyev, Mauro M Teixeira, Danielle G Souza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3362616?pdf=render

Internet

http://europepmc.org/articles/PMC3362616?pdf=render

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