Single- and Multiple-Dose Trials to Determine the Pharmacokinetics, Safety, Tolerability, and Sex Effect of Oral Ginsenoside Compound K in Healthy Chinese Volunteers

Single- and Multiple-Dose Trials to Determine the Pharmacokinetics, Safety, Tolerability, and Sex Effect of Oral Ginsenoside Compound K in Healthy Chinese Volunteers

Background and objectives: Ginsenoside compound K (CK) is a candidate drug for rheumatoid arthritis therapy. The objective of this study was to investigate the pharmacokinetic properties, safety and tolerability of CK.Methods: In randomized, double-blind trials, 76 healthy Chinese subjects received...

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Bibliographic Details
Main Authors: Lulu Chen, Luping Zhou, Jie Huang, Yaqin Wang, Guoping Yang, Zhirong Tan, Yicheng Wang, Gan Zhou, Jianwei Liao, Dongsheng Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
ginsenoside compound K
pharmacokinetics
rheumatoid arthritis
sex factor
tolerability
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00965/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00965/full

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