Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

[11C](R)PK11195-PET is a marker of activated microglia while [11C]PIB-PET detects raised amyloid load. Here we studied in vivo the distributions of amyloid load and microglial activation in Alzheimer's disease (AD) and their relationship with cognitive status. Thirteen AD subjects had [11C](R)P...

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Bibliographic Details
Main Authors: Paul Edison, Hilary A. Archer, Alexander Gerhard, Rainer Hinz, Nicola Pavese, Federico E. Turkheimer, Alexander Hammers, Yen Fong Tai, Nick Fox, Angus Kennedy, Martin Rossor, David J. Brooks
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Neurobiology of Disease
Subjects:
Alzheimer
Amyloid
Microglia
PIB
PK11195
PET
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001885

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108001885

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