Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

Serine arginine (SR) proteins are a family of mRNA regulatory proteins that can modulate spliceosome association with different splice sites and therefore regulate alternative splicing. Phosphorylation within SR proteins is necessary for splice-site recognition, and this is catalyzed by SR protein k...

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Bibliographic Details
Main Authors: Richard B. Tunnicliffe, William K. Hu, Michele Y. Wu, Colin Levy, A. Paul Mould, Edward A. McKenzie, Rozanne M. Sandri-Goldin, Alexander P. Golovanov
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
phosphorylation
splicing
herpes simplex virus
structure
sr protein kinase
Online Access:https://doi.org/10.1128/mBio.02551-19

Internet

https://doi.org/10.1128/mBio.02551-19

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