Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening
In many somatic human tissues, telomeres shorten progressively because of the DNA end replication problem. Consequently, cells cease to proliferate and are maintained in a metabolically viable state called replicative senescence. These cells are characterized by an activation of DNA damage checkpoin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00101/full |