Target-dependent biogenesis of cognate microRNAs in human cells

MicroRNAs are a widespread regulatory mechanism and are themselves extensively regulated. Here the authors show regulated miRNA biogenesis by the target mRNA, a layer of regulation that modulates miRNA levels dependent on target availability.

Bibliographic Details
Main Authors: Mainak Bose, Suvendra N. Bhattacharyya
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12200