Metformin Attenuates ROS via FOXO3 Activation in Immune Cells

Metformin Attenuates ROS via FOXO3 Activation in Immune Cells

Forkhead box O 3 (FOXO3) is a transcription factor involved in cell metabolism, inflammation and longevity. Here, we investigated if metformin can activate FOXO3 in human immune cells and affects the subsequent level of reactive oxygen/nitrogen species (ROS/RNS) in immune cells. AMP-activated protei...

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Bibliographic Details
Main Authors: Jelka Hartwig, Madlen Loebel, Sophie Steiner, Sandra Bauer, Zehra Karadeniz, Carsten Roeger, Carsten Skurk, Carmen Scheibenbogen, Franziska Sotzny
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
metformin
FOXO3
AMPK
reactive oxygen species
immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.581799/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.581799/full

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