Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that generate within-subject epitope diversity. Compre...

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Bibliographic Details
Main Authors: Peter Hraber, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, Gerald H. Learn, Edward F. Kreider, Yingying Li, George M. Shaw, Beatrice H. Hahn, David C. Montefiori, S. Munir Alam, Mattia Bonsignori, M. Anthony Moody, Hua-Xin Liao, Feng Gao, Barton F. Haynes
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Viruses
Subjects:
human immunodeficiency virus type 1
vaccine
neutralizing antibodies
immunogen design
envelope glycoprotein
coevolution
immune escape
quasispecies
antigenic swarm
selection
Online Access:http://www.mdpi.com/1999-4915/7/10/2881

Internet

http://www.mdpi.com/1999-4915/7/10/2881

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