Bavachin Protects Human Aortic Smooth Muscle Cells Against β-Glycerophosphate-Mediated Vascular Calcification and Apoptosis via Activation of mTOR-Dependent Autophagy and Suppression of β-Catenin Signaling

Bavachin Protects Human Aortic Smooth Muscle Cells Against β-Glycerophosphate-Mediated Vascular Calcification and Apoptosis via Activation of mTOR-Dependent Autophagy and Suppression of β-Catenin Signaling

Vascular calcification is a major complication of cardiovascular disease and chronic renal failure. Autophagy help to maintain a stable internal and external environment that is important for modulating arteriosclerosis, but its pathogenic mechanism is far from clear. Here, we aimed to identify the...

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Bibliographic Details
Main Authors: Hu-Qiang He, Betty Yuen Kwan Law, Ni Zhang, Cong-ling Qiu, Yuan-Qing Qu, An-Guo Wu, Yu Han, Qi Song, Wen-Lu Zheng, Yong Liu, Yan-Zheng He, Vincent Kam Wai Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
vascular calcification
autophagy
Wnt/β-catenin
Apoptosis
Atg7
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01427/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01427/full

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