In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.

In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.

Regulatory T cells (T(reg) cells) are increased in context of malignancies and their expansion can be correlated with higher disease burden and decreased survival. Initially, interleukin 2 (IL-2) has been used as T-cell growth factor in clinical vaccination trials. In murine models, however, a role...

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Bibliographic Details
Main Authors: Marc Beyer, Beatrix Schumak, Martin R Weihrauch, Bettina Andres, Thomas Giese, Elmar Endl, Percy A Knolle, Sabine Classen, Andreas Limmer, Joachim L Schultze
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3262821?pdf=render

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http://europepmc.org/articles/PMC3262821?pdf=render

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