USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A165b alternative splicing via regulating SRSF1 and SRPK1

Abstract Background The benefit of targeted therapy for renal cell carcinoma (RCC) is largely crippled by drug resistance. Rapid disease progression and poor prognosis occur in patients with drug resistance. New treatments demand prompt exploration for clinical therapies. Ubiquitin-specific peptidas...

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Bibliographic Details
Main Authors: Xiu-wu Pan, Da Xu, Wen-jin Chen, Jia-xin Chen, Wei-jie Chen, Jian-qing Ye, Si-shun Gan, Wang Zhou, Xu Song, Lei Shi, Xin-gang Cui
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
Renal cell carcinoma
USP39
VEGF-A alternative splicing
SRPK1
SRSF1
Online Access:https://doi.org/10.1186/s12935-021-02161-x

Internet

https://doi.org/10.1186/s12935-021-02161-x

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