Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking

Opioids are the most effective analgesics, with most clinically available opioids being agonists to the µ-opioid receptor (MOR). The MOR is also responsible for their unwanted effects, including reward and opioid misuse leading to the current public health crisis. The imperative need for safer, non-...

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Bibliographic Details
Main Authors: Maria Dumitrascuta, Marcel Bermudez, Olga Trovato, Jolien De Neve, Steven Ballet, Gerhard Wolber, Mariana Spetea
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
µ-opioid receptor
nociceptin receptor
multitarget ligands
inflammatory pain
side effects
reward
Online Access:https://www.mdpi.com/1420-3049/26/11/3267

Internet

https://www.mdpi.com/1420-3049/26/11/3267

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