Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

We used functional -omics angles and examined transcriptomic heterogeneity in CD4+Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int-Treg), and visceral adipose tissue (VAT-Treg), and made significant findings: 1) Five new shared Treg genes including NIBAN,...

Full description

Bibliographic Details
Main Authors: Ruijing Zhang, Keman Xu, Ying Shao, Yu Sun, Jason Saredy, Elizabeth Cutler, Tian Yao, Ming Liu, Lu Liu, Charles Drummer IV, Yifan Lu, Fatma Saaoud, Dong Ni, Jirong Wang, Yafeng Li, Rongshan Li, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
CD4+Foxp3+ regulatory T cells (Treg)
Treg transcription factors (TFs)
Treg CD markers
Treg secretome
stem cell secretomes and TFs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.632239/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.632239/full

Similar Items