Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the present study, we reconstructed ancestral kinases to st...

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Bibliographic Details
Main Authors: Dajun Sang, Sudarshan Pinglay, Rafal P Wiewiora, Myvizhi E Selvan, Hua Jane Lou, John D Chodera, Benjamin E Turk, Zeynep H Gümüş, Liam J Holt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
protein kinase
ancestral reconstruction
evolution
erk
extracellular regulated kinase
Online Access:https://elifesciences.org/articles/38805

Internet

https://elifesciences.org/articles/38805

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