RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5

The small GTPase RAC1B functions as a powerful inhibitor of transforming growth factor (TGF)-β1-induced epithelial-mesenchymal transition, cell motility, and growth arrest in pancreatic epithelial cells. Previous work has shown that RAC1B downregulates the TGF-β type I receptor ALK...

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Bibliographic Details
Main Authors: Hannah Otterbein, Koichiro Mihara, Morley D. Hollenberg, Hendrik Lehnert, David Witte, Hendrik Ungefroren
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
RAC1B
ALK5
PAR2
cell migration
pancreatic carcinoma
RNA interference
TGF-β
Online Access:https://www.mdpi.com/2072-6694/11/8/1211

Internet

https://www.mdpi.com/2072-6694/11/8/1211

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