Prolonged Infusion of β-Lactams Decreases Mortality in Patients with Septic Shock: A Retrospective before-and-after Study

Prolonged Infusion of β-Lactams Decreases Mortality in Patients with Septic Shock: A Retrospective before-and-after Study

Septic shock substantially alters the pharmacokinetic properties of β-lactams with a subsequently high risk of insufficiently low serum concentrations and treatment failure. Considering their pharmacokinetic (PK)/pharmacodynamic (PD) index, prolonged infusions (PI) of β-lactams extend the time that...

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Bibliographic Details
Main Authors: Daniel Christoph Richter, Maximilian Dietrich, Lazar Detelinov Lalev, Felix C. F. Schmitt, Mascha Onida Fiedler, Thomas Bruckner, Dominic Stoerzinger, Ute Chiriac, Sabrina Klein, Thilo Hackert, Thorsten Brenner, Alexander Brinkmann, Markus A. Weigand
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antibiotics
Subjects:
prolonged infusion
β-lactams
septic shock
mortality
antibiotic therapy
critical care
Online Access:https://www.mdpi.com/2079-6382/10/6/687

Internet

https://www.mdpi.com/2079-6382/10/6/687

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