TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function is decreased in multiple models of pulmonary hypertension (PH) including lambs with increased pulmonary blood flow (PBF) and pressure (Shunt). However, the potential link between TGF-β1 and the loss of mitoc...

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Bibliographic Details
Main Authors: Xutong Sun, Qing Lu, Manivannan Yegambaram, Sanjiv Kumar, Ning Qu, Anup Srivastava, Ting Wang, Jeffrey R. Fineman, Stephen M. Black
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Mitochondrial bioenergetics
TGF-β1
PPARγ
ROS
NADPH oxidase
Mechanical forces
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720306509

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http://www.sciencedirect.com/science/article/pii/S2213231720306509

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