A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.
As antimicrobial signalling molecules, type III or lambda interferons (IFNλs) are critical for defence against infection by diverse pathogens, including bacteria, fungi and viruses. Counter-intuitively, expression of one member of the family, IFNλ4, is associated with decreased clearance of hepatiti...
Main Authors: | Connor G G Bamford, Elihu Aranday-Cortes, Ines Cordeiro Filipe, Swathi Sukumar, Daniel Mair, Ana da Silva Filipe, Juan L Mendoza, K Christopher Garcia, Shaohua Fan, Sarah A Tishkoff, John McLauchlan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC6181419?pdf=render |
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