Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer

Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer

Abstract Background The protease uPA and its inhibitor PAI-1 play major roles in hemostasis and are also involved in cancer progression. This is mainly caused by their ability to degrade extracellular matrix-facilitating tumor cell migration. This study aimed to investigate the impact of uPA/PAI-1 a...

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Bibliographic Details
Main Authors: Bruno Märkl, Martin Kazik, Nadia Harbeck, Elzbieta Jakubowicz, Reinhard Hoffmann, Thomas Jung, Dieter Steinfeld, Gerhard Schenkirsch, Günter Schlimok, Daniel Oruzio
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Breast cancer
Circulating tumor cells
Proteases
Prognosis
Online Access:http://link.springer.com/article/10.1186/s12885-019-5857-0

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http://link.springer.com/article/10.1186/s12885-019-5857-0

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