Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for Tolerance

Efficient Presentation of Multiple Endogenous Epitopes to Both CD4+ and CD8+ Diabetogenic T Cells for Tolerance

Antigen-specific immunotherapy of type 1 diabetes, typically via delivery of a single native β cell antigen, has had little clinical benefit to date. With increasing evidence that diabetogenic T cells react against multiple β cell antigens, including previously unappreciated neo-antigens that can be...

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Bibliographic Details
Main Authors: Shamael R. Dastagir, Jorge Postigo-Fernandez, Chunliang Xu, James H. Stoeckle, Rebuma Firdessa-Fite, Rémi J. Creusot
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
type 1 diabetes
T cells
tolerance
antigen targeting
antigen presentation
epitope
mimotope
diabetogenic
dendritic cell
stromal cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050116301358

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http://www.sciencedirect.com/science/article/pii/S2329050116301358

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