Development of an Infectious Cell Culture System for Hepatitis C Virus Genotype 6a Clinical Isolate Using a Novel Strategy and Its Sensitivity to Direct-Acting Antivirals

Development of an Infectious Cell Culture System for Hepatitis C Virus Genotype 6a Clinical Isolate Using a Novel Strategy and Its Sensitivity to Direct-Acting Antivirals

Hepatitis C virus (HCV) is classified into seven major genotypes, and genotype 6 is commonly prevalent in Asia, thus reverse genetic system representing genotype 6 isolates in prevalence is required. Here, we developed an infectious clone for a Chinese HCV 6a isolate (CH6a) using a novel strategy. W...

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Bibliographic Details
Main Authors: Mingxiao Chen, Fuxiang Zheng, Guosheng Yuan, Xiaobing Duan, Liang Rong, Junwei Liu, Shengjun Feng, Ziting Wang, Min Wang, Yetong Feng, Qing Zhou, Jinqian Li, Kai Deng, Chunna Li, Jinyu Xia, Guirong Rao, Yuanping Zhou, Yongshui Fu, Yi-Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
hepatitis C virus
genotype
cell culture system
adaptive mutation
consensus sequence
direct-acting antiviral agents
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02950/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02950/full

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