Oncogenic mutations within the β3‐αC loop of EGFR/ERBB2/BRAF/MAP2K1 predict response to therapies

Abstract Background β3‐αC loop is a highly conserved structural domain across oncogene families, which is a switch for kinase activity. There have been numerous researches on mutations within β3‐αC loop in EGFR, but relatively less in ERBB2, BRAF, and MAP2K1. In addition, previous studies mainly foc...

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Bibliographic Details
Main Authors: Biao Zhang, Yongsheng Chen, Pingping Dai, Haoda Yu, Jianhui Ma, Chen Chen, Yan Zhang, Yanfang Guan, Rongrong Chen, Tao Liu, Jiayin Wang, Ling Yang, Xin Yi, Xuefeng Xia, Haitao Ma
Format: Article
Published: Wiley 2020-10-01
Series:Molecular Genetics & Genomic Medicine
Online Access:https://doi.org/10.1002/mgg3.1395