Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism

Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism

Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display different states of activation or “polarization,” notably the so-called inflammatory “M1” and the various alternative “M2” polarizations, characterized by distinct functions. Data regarding the effects of RA an...

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Bibliographic Details
Main Authors: Yannick Degboé, Benjamin Rauwel, Michel Baron, Jean-Frédéric Boyer, Adeline Ruyssen-Witrand, Arnaud Constantin, Jean-Luc Davignon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
macrophage
alternative polarization
anti-TNF agents
TNF
interleukin 10
STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00003/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00003/full

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