Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Propranolol blocks cardiac and neuronal voltage-gated sodium channels

Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches. At plasma concentrations exceeding those required for ß-adrenergic receptor inhibition, propranolol als...

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Bibliographic Details
Main Authors: Dao W Wang, Akshitkumar M Mistry, Kristopher M Kahlig, Jennifer A Kearney, Jizhou eXiang, Alfred L George
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-12-01
Series:Frontiers in Pharmacology
Subjects:
Propranolol
Sodium channel
SCN1A
SCN2A
SCN3A
SCN5A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00144/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2010.00144/full

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