Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect

Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect

Abstract Background The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and the molecular mechanisms of PC4 in breast cancer development and progr...

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Bibliographic Details
Main Authors: Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao, Chunmeng Shi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
PC4
Warburg effect
C-Myc
Metastasis
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12964-019-0348-0

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http://link.springer.com/article/10.1186/s12964-019-0348-0

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