Aging shapes the population-mean and -dispersion of gene expression in human brains

Human aging is associated with cognitive decline and an increased risk of neurodegenerative disease. Our objective for this study was to evaluate potential relationships between age and variation in gene expression across different regions of the brain. We analyzed the Genotype-Tissue Expression (GT...

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Bibliographic Details
Main Authors: Candice Brinkmeyer-Langford, Jinting Guan, Guoli Ji, James Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00183/full