Molecular alterations of isocitrate dehydrogenase 1 and 2 (<it>IDH1 </it>and <it>IDH2</it>) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

Molecular alterations of isocitrate dehydrogenase 1 and 2 (<it>IDH1 </it>and <it>IDH2</it>) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients

<p>Abstract</p> <p>Background</p> <p>Isocitrate dehydrogenase 1 and 2 (<it>IDH1 </it>and <it>IDH2</it>) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mut...

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Bibliographic Details
Main Authors: Chotirat Sadudee, Thongnoppakhun Wanna, Promsuwicha Orathai, Boonthimat Chetsada, Auewarakul Chirayu U
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia
Isocitrate dehydrogenase
Metabolic enzymes
<it>IDH1</it>
<it>IDH2</it>
Cooperative mutations
Normal karyotype
Online Access:http://www.jhoonline.org/content/5/1/5

Internet

http://www.jhoonline.org/content/5/1/5

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