Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

Interleukin-18 Down-Regulates Multidrug Resistance-Associated Protein 2 Expression through Farnesoid X Receptor Associated with Nuclear Factor Kappa B and Yin Yang 1 in Human Hepatoma HepG2 Cells.

Multidrug resistance-associated protein 2 (MRP2) plays an important role in bile acid metabolism by transporting toxic organic anion conjugates, including conjugated bilirubin, glutathione, sulfate, and multifarious drugs. MRP2 expression is reduced in cholestatic patients and rodents. However, the...

Full description

Bibliographic Details
Main Authors: Xiao-cong Liu, Wei Lian, Liang-jun Zhang, Xin-chan Feng, Yu Gao, Shao-xue Li, Chang Liu, Ying Cheng, Long Yang, Xiao-Juan Wang, Lei Chen, Rong-quan Wang, Jin Chai, Wen-sheng Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4546195?pdf=render

Internet

http://europepmc.org/articles/PMC4546195?pdf=render

Similar Items