To what extent is blood a reasonable surrogate for brain in gene expression studies: estimation from mouse hippocampus and spleen

Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether a second, accessible tissue could be used as a surrogate for transcription profiling. Surrogacy has applic...

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Bibliographic Details
Main Authors: Matthew N Davies, Sarah Lawn, Steven Whatley, Cathy Fernandes, Robert W Williams, Leonard C Schalkwyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2009-10-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/neuro.15.002.2009/full