Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients

Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients

Abstract Background Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its somatic mutations are reported in approximately 27% of BC and 43% of CRC...

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Bibliographic Details
Main Authors: Vahinipriya Manoharan, Eric Hamilton Karunanayake, Kamani Hemamala Tennekoon, Sumadee De Silva, Ahamed Ilyas Ahamed Imthikab, Kanishka De Silva, Preethika Angunawela, Sameera Vishwakula, John Lunec
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Cancer
Subjects:
Breast cancer
Colorectal cancer
Sri Lanka
TP53
Genetic variation
Immunohistochemistry
Online Access:https://doi.org/10.1186/s12885-020-6573-5

Internet

https://doi.org/10.1186/s12885-020-6573-5

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