SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) immunotherapy with antibodies targeting amyloid-β (Aβ) has been extensively explored in clinical trials. The aim of this study was to study the long-term brain distribution of two radiolabeled monoclonal Aβ antibody variants – RmAb158, the recombinant mur...

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Bibliographic Details
Main Authors: Tobias Gustavsson, Stina Syvänen, Paul O’Callaghan, Dag Sehlin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Amyloid beta
SPECT
Immunotherapy
Bispecific antibody
Transferrin receptor
Online Access:http://link.springer.com/article/10.1186/s40035-020-00214-1

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http://link.springer.com/article/10.1186/s40035-020-00214-1

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