Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.

Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.

The proteins, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1), act in concert to balance thrombus formation and degradation, thereby modulating the development of arterial thrombosis and excessive bleeding. PAI-1 is upregulated by the renin-angiotensin system (RAS),...

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Bibliographic Details
Main Authors: Nadia M Penrod, Kwabena A Poku, Douglas E Vaughan, Folkert W Asselbergs, Nancy J Brown, Jason H Moore, Scott M Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031598?pdf=render

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http://europepmc.org/articles/PMC3031598?pdf=render

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