Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling.

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling.

Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. Using the super-resolution microscopy methods of OligoSTORM and OligoDN...

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Bibliographic Details
Main Authors: Guy Nir, Irene Farabella, Cynthia Pérez Estrada, Carl G Ebeling, Brian J Beliveau, Hiroshi M Sasaki, S Dean Lee, Son C Nguyen, Ruth B McCole, Shyamtanu Chattoraj, Jelena Erceg, Jumana AlHaj Abed, Nuno M C Martins, Huy Q Nguyen, Mohammed A Hannan, Sheikh Russell, Neva C Durand, Suhas S P Rao, Jocelyn Y Kishi, Paula Soler-Vila, Michele Di Pierro, José N Onuchic, Steven P Callahan, John M Schreiner, Jeff A Stuckey, Peng Yin, Erez Lieberman Aiden, Marc A Marti-Renom, C-Ting Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007872

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https://doi.org/10.1371/journal.pgen.1007872

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