MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway

MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway

This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell prolife...

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Bibliographic Details
Main Authors: Chunyan Wang, Enqi Liu, Wen Li, Jue Cui, Tongxiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
miR-3188
NSCLC
proliferation
mTOR
PI3K/AKT
c-JUN
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01362/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01362/full

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