Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1

Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1

Nucleic acid aptamers hold promise as therapeutic tools for specific, tailored inhibition of protein targets with several advantages when compared to small molecules or antibodies. Nuclear WW domain containing E3 ubiquitin ligase 1 (WWP1) ubiquitin ligase poly-ubiquitinates Runt-related transcriptio...

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Bibliographic Details
Main Authors: Wesley O. Tucker, Andrew B. Kinghorn, Lewis A. Fraser, Yee-Wai Cheung, Julian A. Tanner
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
aptamer
SELEX
ubiquitin ligase
WWP1
targeted drug delivery
Online Access:http://www.mdpi.com/1422-0067/19/3/763

Internet

http://www.mdpi.com/1422-0067/19/3/763

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