Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

Neuronal apoptosis plays key roles in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first reported the role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in alleviating secondary brain injury through anti-apoptosis in rat model of ICH. The recombinant hu...

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Bibliographic Details
Main Authors: Weilin Xu, Liansheng Gao, Tao Li, Jingwei Zheng, Anwen Shao, Jianmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mesencephalic astrocyte-derived neurotrophic factor (MANF)
intracerebral hemorrhage
neuronal apoptosis
secondary brain injury
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00176/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00176/full

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