Effect of TCF7L2 polymorphism on pancreatic hormones after exenatide in type 2 diabetes

Effect of TCF7L2 polymorphism on pancreatic hormones after exenatide in type 2 diabetes

Abstract Background Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and reduces blood glucose in type 2 diabetes mellitus (T2DM). TCF7L2 rs7903146 polymorphism has been associated with decreased insulin secretion, reduced GLP-1 action, and possible impaired peripheral insulin sensitivit...

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Bibliographic Details
Main Authors: Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Salman Azhar, Rosa Ferreira dos Santos
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Postprandial period
Glucagon-like peptide 1
Polymorphism
Single nucleotide
Proinsulin
Insulin
Online Access:http://link.springer.com/article/10.1186/s13098-019-0401-6

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http://link.springer.com/article/10.1186/s13098-019-0401-6

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