Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcripto...

Full description

Bibliographic Details
Main Authors: Helen M Tauc, Imilce A Rodriguez-Fernandez, Jason A Hackney, Michal Pawlak, Tal Ronnen Oron, Jerome Korzelius, Hagar F Moussa, Subhra Chaudhuri, Zora Modrusan, Bruce A Edgar, Heinrich Jasper
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
aging
lineage fidelity
chromatin
intestinal stem cell
transcriptome
Polycomb
Online Access:https://elifesciences.org/articles/62250

Internet

https://elifesciences.org/articles/62250

Similar Items