Age-dependent degeneration of mature dentate gyrus granule cells following NMDA receptor ablation

Age-dependent degeneration of mature dentate gyrus granule cells following NMDA receptor ablation

N-methyl-D-aspartate receptors (NMDARs) in all hippocampal areas play an essential role in distinct processes of memory formation as well as in sustaining cell survival of postnatally-generated neurons in the dentate gyrus (DG). In contrast to the beneficial effects, over-activation of NMDARs has be...

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Bibliographic Details
Main Authors: Yasuhito eWatanabe, Michaela K. Müller, Jakob evon Engelhardt, Rolf eSprengel, Peter H Seeburg, Hannah eMonyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Aging
Dentate Gyrus
Hippocampus
Mouse
neurodegeneration
NMDA receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00087/full

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