An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons

An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons

Abstract Background Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of tight junction proteins, a host of active efflux and nutrient transporte...

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Bibliographic Details
Main Authors: Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek, Eric V. Shusta
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Isogenic model
Human induced pluripotent stem cells
Neurovascular unit
Online Access:http://link.springer.com/article/10.1186/s12987-019-0145-6

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http://link.springer.com/article/10.1186/s12987-019-0145-6

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