Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Abstract Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component. Immunofluorescence studies demonstrated that infecti...

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Bibliographic Details
Main Authors: Aileen Harrer, Roland Bücker, Manja Boehm, Urszula Zarzecka, Nicole Tegtmeyer, Heinrich Sticht, Jörg D. Schulzke, Steffen Backert
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Gut Pathogens
Subjects:
Occludin
Tight junction
E-cadherin
Campylobacter
Protease
HtrA
Online Access:http://link.springer.com/article/10.1186/s13099-019-0283-z

Internet

http://link.springer.com/article/10.1186/s13099-019-0283-z

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